Rheumatic heart disease is a persistent, preventable ailment afflicting children and young adults worldwide, with a significant impact in Sub-Saharan Africa. The African Heart Network (AHN) actively works to enhance African cardiovascular health through prevention, early detection, and advanced treatment, while also promoting CVD awareness campaigns. Lessons from countries like Tunisia, Uganda, and Kenya, which have successfully combatted RHD through comprehensive programs, offer valuable guidance for other nations aiming to eliminate this disease and improve cardiovascular health.